Research

Stanford University Medical Center, Department of Medicine (2015-present)

Research Summary: Clinical outcomes in acute leukemia. Quality of life during and after cancer treatment. Health care delivery models for cancer survivorship. Improving advance care planning and communication at the end of life.

Selected Publications

  • Yurkiewicz IR, Coutre S, Ghesquieres H, Pastan I, Kreitman RJ. Moxetumomab Pasudotox as Re-Treatment for Heavily-Pretreated Relapsed Hairy Cell Leukemia. Leukemia & Lymphoma. 2021.

  • Yurkiewicz IR, Zhou M, Ganjoo KN, Charville GW, Bolleddu S, Lohman M, Bui N. Management Strategies for Patients with Epithelioid Hemangioendothelioma: Charting an Indolent Disease Course. American Journal of Clinical Oncology. 2021.

  • Muffly L, Sundaram V, Chen C, Yurkiewicz I, Kuo E, Burnash S, Spiegel JY, Arai S, Frank MJ, Johnston LJ, Lowsky R, Meyer EH, Negrin RS, Rezvani AR, Sidana S, Shiraz P, Shizuru JA, Weng WK, Liedtke M, Vempaty HT, Miklos DB. Concordance of peripheral blood and bone marrow measurable residual disease in adult acute lymphoblastic leukemia. Blood Advances. 2021.

  • Yurkiewicz I, Craig J, Muffly L. Hematopoietic Cell Transplantation for Philadelphia Chromosome Negative Adult Acute Lymphoblastic Leukemia in the Modern Era of Immune Therapy. Current Hematologic Malignancy Reports. 2020; 15(3):187-193.

  • Badar T, Szabo A, Advani A, Wadleigh M, Arslan S, Khan MA, Aldoss I, Siebenaller C, Schultz E, Hefazi M, Shallis RM, Yurkiewicz I, Podoltsev N, Patel AA, Curran E, Balasubramanian S, Yang J, Mattison RJ, Burkart M, Dinner S, Liedtke M, Litzow MR, Atallah E. Real-world outcomes of adult B-cell acute lymphoblastic leukemia patients treated with blinatumomab. Blood Advances. 2020; 4(10):2308-2316.

  • Saygin C, Kishtagari A, Cassaday RD, Reizine N, Yurkiewicz I, Liedtke M, et al. Therapy-related acute lymphoblastic leukemia is a distinct entity with adverse genetic features and clinical outcomes. Blood Advances. Dec 2019; 3(24): 4228-4237.

  • Yurkiewicz IR, Muffly L, Liedtke M. Inotuzumab ozogamicin: a CD22 mAb-drug conjugate for adult relapsed or refractory B-cell precursor acute lymphoblastic leukemia. Drug Design, Development and Therapy. 2018; 12: 2293-2300.

  • Yurkiewicz IR, Simon P, Liedtke M, Dahl G, Dunn T. Effect of Fitbit and iPad Wearable Technology in Health-Related Quality of Life in Adolescent and Young Adult Cancer Patients. Journal of Adolescent and Young Adult Oncology. 2018; 7(5):579-583.

  • Yurkiewicz IR, Ganjoo KN, Iagaru A. Anaplastic Thyroid Cancer With Extensive Skeletal Muscle Metastases on 18F-FDG PET/CT. Clinical Nuclear Medicine. 2018; 43(4): e113-e114.

Conference Presentations and Posters

  • 20th Multidisciplinary Management of Cancers: A Case-Based Approach. Hematologic Malignancies Tumor Board Cases. Napa, CA (held virtually during COVID). 2020.

  • Yurkiewicz IR. A 33-year-old woman with thrombocytopenia. In Molecular Hematopathology Tumor Board. Stanford’s Review of the 60th Annual American Society of Hematology Meeting. Half Moon Bay, CA. 2019.

  • Yurkiewicz IR, Periyakoil VJ, Klein L, Shieh L. Improving Advance Care Planning in Hospitalized Patients with a Letter Project. Society of Hospital Medicine. Las Vegas, NV. 2017 [Poster Presentation].

Harvard Medical School, Division of Medical Ethics (2011-2015)

Principal Investigator: Dr. Lisa Lehmann

Research Summary: Empirical and normative research on returning genetic risk information to patients and research participants.

Thesis: To Return or Not to Return? IRB Perspectives on Obligations to Return Genetic Incidental Findings to Research Participants

Selected Publications

  • Yurkiewicz IR, Korf RB, and Lehmann LS. Prenatal Whole-Genome Sequencing — Is the Quest to Know a Fetus’s Future Ethical? New England Journal of Medicine. 2014; 370:195-197.

  • Gliwa C, Yurkiewicz IR, Lehmann LS, Hull SC, Jones N, Berkman BE. Institutional review board perspectives on obligations to disclose genetic incidental findings to research participants. Genetics in Medicine. 2016; 18(7):705-11.

Abstracts and Conference Presentations

  • Yurkiewicz IR, Fickie MR, Lehmann LS. Role of numeracy and genetic literacy in the desire to receive genetic risk information. National Society of Genetic Counselors Annual Education Conference. Boston, MA. 2012

  • Berkman BE, Hull SC, Gliwa C, Yurkiewicz IR. A Quantitative Study of Perspectives on Genetic Incidental Findings. American Society for Bioethics and Humanities 15th Annual Meeting. Atlanta, GA. 2013.

Walter Reed Army Medical Center, Department of Orthopedics & Rehabilitation (2010-2011)

Principal Investigator: Dr. Jack Tsao

Research Summary: Treatment of phantom limb pain using mirror therapy in military amputees. Use of telemedicine to improve neurology outcomes for combatants oversees.

Selected Publications

  • Yurkiewicz IR, Lappan CM, Neely ET, Hesselbrock RR, Girard PD, Alphonso AL, Tsao JW. Outcomes from a US Military Neurology and Traumatic Brain Injury Telemedicine Program. Neurology. 2012 Sep 18;79(12):1237-43.

  • Swanberg KM, Clark AM, Kline JE, Yurkiewicz IR, Chan BL, Pasquina PF, Heilman KM, Tsao, JW. Enhanced Left Finger Deftness Following Dominant Upper and Lower Limb Amputation. Neurorehabilitation and Neural Repair. 2011 Sep;25(7):680-4.

  • Tsao JW, Yurkiewicz IR, Monson B, Chan BL, Hussey-Anderson L. Hughes KE, Witt R, Heilman KM, Pasquina PF. Use of Mirror Therapy for the Treatment of Phantom Limb Pain. Frontiers in Neurotrauma. 2011; 2(29): 3-5.

  • Tsao JW, Alphonso AL, Griffin SC, Yurkiewicz IR, Ling GSF. Neurology and the military: Five new things. Neurology Clinical Practice. 2013 3:30-38.

  • Wechsler LR, Tsao JW, Levine SR, Swain-Eng RJ, Adams RJ, Demaerschalk BM, Hess DC, Moro E, Schwamm LH, Steffensen S, Stern BJ, Zuckerman SJ, Bhattacharya P, Davis LE, Yurkiewicz IR, Alphonso AL; American Academy of Neurology Telemedicine Work Group. Teleneurology applications: Report of the Telemedicine Work Group of the American Academy of Neurology. Neurology. 2013 Feb 12;80(7):670-6.

Book Chapters

  • Yurkiewicz IR, Pasquina P, Goldberg M, Drach R (2011). Army Programs Related to Warriors in Transition. In Cooper R., Pasquina P. & Drach R. (Eds.), Warrior Transition Leader Medical Rehabilitation Handbook. Washington DC: Borden Institute.

Book Reviews

  • Yurkiewicz IR & Tsao JW. (15 February 2012) Book Review of Why People Get Lost: The Psychology and Neuroscience of Spatial Cognition. Journal of the Neurological Sciences, 313(1-2), 197-8.

  • Yurkiewicz IR & Tsao JW. (15 February 2012). Book Review of Dementia Care: A Practical Manual. Journal of the Neurological Sciences, 313(1-2), 198.

  • Yurkiewicz IR & Tsao JW. (15 Jan 2011). Book Review of The Neurophysiological Foundations of Mental and Motor Imagery. Journal of the Neurological Sciences, 300(1-2), 202.

Yale School of Medicine, Department of Genetics (2007-2010)

Principal Investigator: Dr. Matthew State (now at UCSF)

Research Summary: Genomics research on copy number variations in autism spectrum disorders and Tourette syndrome. Bioinformatics research on error rate reduction in next-generation sequencing and alignment.

Thesis: Analysis of Error Rate in Next-Generation Sequencing and Alignment

Selected Publications

  • Fernandez TV, Sanders S, Yurkiewicz IR, Ercan-Sencicek AG, Kim YS, Fishman DO, Raubeson MJ, Song Y, Yasuno K, Ho W, Bilguvar K, Glessner J, Chu SH, Leckman JF, King RA, Gilbert DL, Heiman GA, Tischfield JA, Hoekstra PJ, Devlin B, Hakonarson H, Mane SM, Gunel M, State MW. Rare Copy Number Variants in Tourette Syndrome Disrupt Genes in Histaminergic Pathways and Overlap with Autism Risks. Biological Psychiatry. 2011.

  • Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha M, Moreno-De-Luca D, Chu SH, Moreau M, Gupta A, Thomson SA, Mason CE, Bilguvar K, Celestino-Soper PBS, Choi M, Crawford EL, Davis L, Davis Wright NR, Dhodapkar RM, DiCola M, DiLullo NM, Fernandez TV, Fielding-Singh V, Fishman DO, Frahm S, Goh GS, Kammela S, Klei L, Lowe JK, Lund SC, McGrew AD, Meyer KA, Moffat WJ, O’Roak BJ, Ober G, Pottenger RS, Raubeson MJ, Song Y, Wang Q, Yaspan BL, Yu TW, Yurkiewicz IR, Beaudet AL, Cantor RM, Grice DE, Günel M, Lifton RP, Mane SM, Martin DM, Shaw CA, Sheldon M, Tischfield JA, Walsh CA, Morrow EM, Ledbetter DH, Fombonne E, Lord C, Martin CL, Brooks AI, Sutcliffe J, Cook, Jr. EH, Geschwind D, Roeder K, Devlin B, State MW. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. 2011; 70(5): 863-85.

Columbia University Medical Center, Department of Radiation Oncology (2004-2005)

Principal Investigator: Dr. Tom Hei

Research Summary: Epigenetic inactivation of BigH3 tumor suppressor gene in lung cancer.

Other Academic Publications

  • Yurkiewicz IR. “My Brain Made Me Do It”: Can Neuroimaging Undermine the Case for Criminal Punishment? Penn Bioethics Journal. 2011; 6(2): 14-15.

  • Yurkiewicz IR. The Prisoner Dis-Analogy as a Defense of Stem Cell Research on Spare Embryos. Ivy Journal of Ethics. 2009; 9(2): 6-11.

  • Yurkiewicz IR. Overlooked and Under-diagnosed: Distinct Expression of Asperger’s Syndrome in Females. Yale Review of Undergraduate Research in Psychology. 2009; 1(1): 78-88.